segunda-feira, 1 de março de 2010

Breast cancers may be an iodine deficiency disease

    What if there was one nutrient which?
    1Desensitized estrogen receptors in the breast.
    2. Reduced estrogen production in overactive ovaries.
    3Reduced fibrocystic breast disease which often precedes breast cancer. 4Caused more cell death than the chemo drug, Fluorouracil .
    5Prevented rats from getting cancer when they were fed the breast cancer  causing toxin DMBA.

    Research suggests that some breast cancers may be an iodine deficiency disease. As iodine consumption has gone down, breast cancer rates have gone up. But the research goes far deeper, exploring the effects of iodine supplementation on breast disease and breast cancer. This important breakthrough has been in the research pipeline for years but only recently found momentum.  After sifting through 50 years of iodine research and corresponding with researchers around the world, the editors report that abnormal iodine metabolism, due either to bromide dominance in the environment or a dietary deficiency of iodine, must be addressed as part of a preventive and or a therapeutic strategy.  
                                  Iodine Deficiency Growing Worse
  • Iodine consumption by Americans has dropped 50% since the 1970s as breast cancer rates have risen (1) In the US Goiter Belt,  where iodine in the soil is
    lower, breast  cancer is higher (2).

  • By contrast, the incidence and severity of breast cancer are less in Japan than
    in Europe and the US, attributable to the diet (3).  Japanese women consume 25 times more dietary iodine than North American women and have lower breast cancer rates (4).
  • Meanwhile, since the 1970s, in the US and several other countries, iodine-blocking bromides have been added to flour,  some sodas, and medications, exacerbating the iodine deficiency.

  • Fluoridated drinking water also depletes iodine absorption. Thus, as women
    consume less iodine and excrete more due to toxic elements, our risk for breast cancer grows(5).
                   Iodine and Benign Breast Disease
  • Blocking iodine in rats' food supply led to progressive human-like fibrocystic
    disease (atypia, sclerosing, calcifications, dysplastic changes) as the rats aged (6). Supplementing patients with fibrocystic disease with iodine helped to resolve fibrosis and reduced breast size (7).
  • For women with painful breasts accompanying fibrocystic disease, iodine  
    improved symptoms in more than 50% of the women who took 6.0 mg. of iodine for 6 months (8), and brown sea alga improved pain and nodularity in 94% of the women (9).  From the editors' observations of the Iodine Investigation Project participants, depending on the kind of iodine agent used, painful breast symptoms have resolved in from 24 hours to two months.
  • Since benign breast disease increases the risk of breast cancer (10), and iodine improves fibrocystic disease, we at Breast Cancer Choices propose studies to see if iodine supplementation decreases the risk of getting breast cancer and the risk orecurrence.
                                           Iodine and Breast Cancer        
  • For breast patients, iodine's therapeutic mechanisms of action may be at least
    three-pronged:  Hormonal (11),  Biochemical (12-18), Genetic (19). That is, iodine desensitizes the estrogen receptors, alters the chemical pathways as well effects on the genes, resulting in less cell growthand causing anti-tumor effect by causing apoptosis (programmed cell death) of malignant cells.
  • Iodine-rich seaweed exhibits an anti-cancer effect in rats and in the lab on human breast cancer cells.

    Adding seaweed to rats' food delays the onset and number of rat mammary tumors (20,21). And in the lab, mekabu seaweed plant induced cell death in three kinds of human breast cancer cells. Mekabu had a stronger effect on the cells than the chemo drug, 5-fluorouracil (22).

  • Adding  iodine to chemically-induced (DMBA) rat breast tumors stops the
    growth of the tumors.  Adding iodine plus medroxyprogesterone gave the highestlevel of response: the growth-suppressed tumors showed 100% times the iodine content than the full blown (nonsuppressed) tumorsThe researchers suggest that the uptake of iodine was enhanced by medroxyprogesterone. (23).  As David Brownstein, MD, phrased it, "You cannot give breast cancer to rats that have sufficient iodine."

  • In small, preliminary patient studies, using the screening iodine-loading test, breast cancer patients excreted less urinary iodine than healthy people, implying iodine-deficiency (24,25).

              What to do about iodine deficiency?
  • The editors at Breast Cancer Choices recommend patients read as much as they
    can from the Iodine Related Links on the top left side of this page.
  • Secondly,  we recommend taking the Iodine Loading Test  which will provide a guideline to your current iodine sufficiency status. Then join the Iodine Investigation Project and participate in our confidential database so we can follow your progress. Next, consider finding an iodine-literate practioner (ILP from our directory or one willing to consider this non-toxic therapy.

  • Iodine ProtocolDepending upon the results of your screening iodine-loading test,  most doctors we are familiar with currently recommend 50 mg or more of iodine daily in the form of Iodoral tablets (a combined iodine-iodide formula), but others recommend an iodine-only formulation or Lugol's iodine solution.

  • Where to Get Iodoral:  Iodoral tablets may be available from your health practitioner. The Breast Cancer Choices charity fund-raises for the Iodine investigation Project through sales of Iodoral. If we have provided information to you, please consider buying from a charity rather than a for-profit company.
  • Iodine Companion Nutrients. Many Iodine Literate Doctors suggest selenium(26),  vitamin C (27), and magnesium(28) enhance the therapeutic value of iodine. Niacin was also recommended at the February 07 Iodine Conference. Thyroid function should be closely monitored and may require an adjustment of thyroid medications.

  • For those experiencing uncommon detox side effects such as constipation, acne or rash,the Yahoo Iodine Group has used 1/2 teaspoon Celtic salt dissolved in a large glass of water, taken twice a day. Drinking additional water and taking extra vitamin C may help even more.  

                                  What to Expect The Breast Cancer Choices Iodine Investigation Project is currently following patients taking iodine to prevent recurrence. Most patients report no side effects.  Some report a range of non-breast improvements such as change in thyroid status, need for less thyroid medication, weight loss, ovarian cysts resolving, fibroids shrinking, improved energy, mood and mental clarity. But be aware  some iodine takers report what we believe to be iodine detoxing bromide into the bloodstream causing symptoms of bromism. According to a Department of Defense commissioned report, , bromism symptoms can manifest as lethargy, depression, "dark" thoughts, "brain fog," constipation, leg and hip pain, acne, rashes and other symptoms. These side effects are usually reversible in 24-48 hours by discontinuing the iodine and allowing a short period of washout before restarting at a lower dose. Again, as stated above, Celtic salt in water has relieved detox symptoms quickly by speeding up bromide detox through the kidneys. See Iodine Protocol. CAUTION:  DO NOT TAKE IODINE IF YOU ARE ALLERGIC TO IODIZED SALT
Since bromide excretion seems to be higher in breast cancer patients than
undiagnosed persons (29), it is important that each patient develop a strategy with her physician to clear the bromide. Ways of eliminating bromide detox symptoms by taking 1/2 teaspoon of Celtic salt in water are currently being used.
    References: 1. NHANES.  National Health and Nutrition Survey showed iodine levels have declined 50% in the US. CDC National Center for Health Statistics.  CDC. gov 2000. 2. Eskin BA., Iodine and Mammary Cancer, Tans NY, Academy of Sciences 1970. 3. Kurihara M., "Cancer Statistics in the World," Nagoya Univ. Press, Nagoya, pp. 80-81 1984. 4. Aceves C., et al., Is Iodine a Gatekeeper of the Integrity of the Mammary Gland?, Journal of Mammary Gland Biology and Neoplasia, 2005.   5. Brownstein D., Iodine.  Why You Need It.  Why You Can't Live Without It, 2nd Edition, Medical Alternative Press 2006. 6. Krouse TB et al., Age-Related Changes Resembling Fibrocystic Disease in Iodine-Blocked Rat Breasts, Arch Pathol Lab Med, 1979 7. Ghent WR et al., Iodine Replacement in Fibrocystic Disease of the Breast, Can J Surg 1993. 8.  Kessler J, The Effect of Supraphysiologic Levels of Iodine in Patients with Cyclic Mastalgia, The Breast Journal 2004. 9. Bezpalov VG et al., Investigation of the Drug "Mamoclam" for the Treatment of Patients with Fibroadenomatosis of the Breast, Vopr Onkol, 2005. 10. Hartmann LC et al., Benign Breast Disease and the Risk of Breast Cancer, N Engl J Med 2005. 11. Shah NM et al., Iodoprotein Formation by Rat Mammary Glands During Pregnancy and Early Postpartum Period, Proc Soc Exp 1986 12.Venturi S., Is There a Role for Iodine in Breast Disease?, The Breast  2001. 13.Cann SA., et al., Hypothesis:  Iodine, Selenium, and the Development of Breast Cancer, Cancer Causes control 2000. 14.Smyth PP., Role of Iodine in Antioxidant Defence in Thyroid and Breast Disease, Biofactors 2003. 15.Coochi M. et al., A New Hypothesis of Bio-Chemical Cooperation?, Prog Nutr 2000. 16.Thrall KD., Differences in the Distribution of Iodine and Iodide in the Sprague-Dawley Rats, J Toxicol Environ Health 1992. 17. Eskin BA.,et al., Different Tissue Responses for Iodine and Iodide in Rat Thyroid and Mammary Glands, Biol Trace Elem Res 1995. 18.Ghent WR. et al., IBID. 19. Eskin BA. et al., Microarray Characterization of Iodine Metabolic Pathways in Breast Cancer, p. 379 2006. 20. Teas J. et al., Dietary Seaweed (Laminaria) and Mammary Carcinogens in Rats, Cancer Res 1984. 21. Funahashi H. et al., Wakame Seaweed Suppresses the Proliferation of 7,12-Dimethybenz(a)- Anthracene-Induced Mammary Tumors in Rats, Jpn J Cancer Res 1999. 22. Funahashi H. et al., Seaweed Preventing Breast Cancer?, Jpn J Cancer Res 2001. 23. Funahashi H. et al., Suppressive Effect of Iodine on DMBA-Induced Breast Tumor Growth in the Rat, J Surg Oncol 1996. 24. Eskin BA. et al., Identification of Breast Cancer by Differences in Urinary Iodine, Abstract Number 2150, Presentation AACR Conference 2005. 25. Brownstein D., IBID 26. Cann SA. et al.,  IBID. 27. Abraham GE., et al., Evidence that the Administration of Vitamin C Improves a Defective Cellular Transport Mechanism for Iodine:  A Case Report, The Original Internist 2005. 28. Abraham GE., The Safe and Effective Implementation of Orthoiodosupplementation in Medical Practice, The Orginal Internist 2004. 29. Brownstein D., IBID. The statements above have not been evaluated by the U.S. Food & Drug Administration.  The supplements discussed are not intended to diagnose, treat, cure, or prevent any disease.  Do not take iodine without the supervision of an Iodine-Literate Doctor who is qualified to interpret lab work in the context of supplementation. This website is intended as information only. The editors of this site are not medically-trained. Please consult your licensed health care practitioner before implementing any health strategy. The information provided on this site is designed to support, not replace, the relationship that exists between a patient/site visitor and his/her existing physician. This site accepts no advertising. The contents of this site are copyrighted 2004-2010 by Breast Cancer Choices, Inc. Contact us with comments or for reprint permission at Web page updated January 18,  2010.

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A minha fotografia

Luis Guerreiro
* Integrando a equipe de preparação dos vários Detoxes de Tony Samara - Portugal - 2009
* Consultor de Alimentação Viva do Spa Natural Alma Verde - Foz do Iguaçu-PR - Junho, Julho 2008.
* Apresentação de pratos vivos - 23º Congresso Internacional de Educação Física - FIEP 2008 - Foz do Iguaçu/PR
* Consultor e Árbitro da FDAP - Federação de Desportos Aquáticos do Paraná - Novembro de 2007 a Maio 2008 - Foz do Iguaçu-PR
* Criação do Instituto IDEIAS - Foz do Iguaçu - Outubro de 2007.
* Palestras de educação Nutriconal e Administração dos Serviços de Alimentação. - IPEC. Instituto de Permacultura e Ecovilas do Cerrado. Pirenópolis. Goiás.
Aula introdutória sobre alimentação e Nutrição para participantes do curso de Ecovilas e administração junto a uma equipe, dos serviços de alimentação fornecidos durante os sete dias de curso. Início: Outubro de 2007.
* Curso de Alimentação Viva- Restaurante Girassol - Ros Ellis Moraes (nutricionista) e Jacqueline Stefânia (nutricionista) - Agosto de 2007 - Brasilia-DF
* Palestras de educação Nutriconal e Administração dos Serviços de Alimentação.
IPEC - Instituto de Permacultura e Ecovilas do Cerrado. Pirenópolis. Goiás.
Actuação: Aula introdutória sobre alimentação e Nutrição para participantes do curso do SEBRAE e administração junto a uma equipe, dos serviços de alimentação fornecidos durante os sete dias de curso - Agosto de 2007. Com Jacqueline Stefânia (nutricionista)
* Administração dos Serviços de Alimentação.
IPEC - Instituto de Permacultura e Ecovilas do Cerrado. Pirenópolis. Goiás.
Atuação: Curso Bioconstruindo - administração junto a uma equipe, dos serviços de alimentação fornecidos durante os dias de curso.
BIOCONSTRUINDO - Julho 2007 - Com Jacqueline Stefânia (nutricionista)
* Palestra sobre Alimentação Viva - Maçonaria - Julho 2007 - Belo Horizonte-MG - Com Jacqueline Stefânia (nutricionista)
* Oficina de Alimentação Viva "Nutriviva" com a Nutricionista Jacqueline Stefânia Pereira e a professora de Hatha Yoga, Ana Virgínia de Azevedo e Souza - Junho 2007 - Belo Horizonte -MG
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